Funding opportunity

Funding opportunity: EPSRC accelerating the medicines revolution: small grants

Apply for funding to revolutionise the development of future medicines. We will fund a diverse portfolio of feasibility studies and translational projects, contributing to solving bottlenecks from discovery to deployment.

You must be based at a UK research organisation eligible for Engineering and Physical Sciences Research Council (EPSRC) funding.

We encourage interdisciplinary projects, and you must consider manufacturability from the outset.

The full economic cost (FEC) of your project can be up to £187,500. EPSRC will fund 80% FEC (£150,000).

Projects can last up to two years.

Who can apply

You can only apply for this funding opportunity if we have invited you to do so following a successful outline application.

Before applying for funding, check the Eligibility of your organisation.

EPSRC standard eligibility rules apply. For full details, visit EPSRC’s eligibility page.

UKRI has introduced new role types for funding opportunities being run on the new Funding Service.

For full details, visit Eligibility as an individual.

Under the UKRI and Research Council of Norway Money Follows Cooperation agreement a project co-lead (international) (previously co-investigator) can be based in a Norwegian institution.

Check if you are eligible for research and innovation funding.

Equality, diversity and inclusion

We are committed to achieving equality of opportunity for all funding applicants. We encourage applications from a diverse range of researchers.

We support people to work in a way that suits their personal circumstances. This includes:

  • career breaks
  • support for people with caring responsibilities
  • flexible working
  • alternative working patterns

Find out more about equality, diversity and inclusion at UKRI.

What we're looking for

Scope

We are seeking high quality research ideas that will address key bottlenecks in the medicines manufacturing pipeline. From discovery to deployment, proposals will facilitate a revolution through speculative, high risk ideas that could potentially offer high reward.

Applicants are advised to strongly consider whether their research or translational idea is truly speculative, high risk and could potentially offer high reward before applying.

Objectives of the opportunity

We expect the studies funded to contribute to one or more of the following objectives:

  • explore the viability of more speculative translational pathways for medicines manufacturing
  • develop novel approaches or fundamental basis for more sustainable pathways
  • investigate disruptive approaches to reduce time from discovery to deployment
  • ensure manufacturability, including scale-up and the needs of users, is considered from the outset of the process of new medicines discovery
  • create the engineering and physical sciences knowledge, skills and workforce to take forward future biological breakthroughs
  • cover research in any part of the pipeline from innovative chemistry to novel manufacturing techniques, including multidisciplinary work where appropriate

Themes

We are looking for proposals to incorporate one or more of the below themes into the wider application:

New modalities:

Sustainable solutions to scale up production of new modalities.

Technologies to consider scale up of new modalities at the outset of drug design.

Discovery:

Techniques to improve understanding at drug screening to ensure higher success rates for scale up.

Analytical Capability:

Analytical techniques for new modalities to predict performance in the clinic, discovery or both, and manufacturing scale up.

We expect environmental sustainability to be a consideration in projects.

Proposals related to vaccine research are not in scope of this funding opportunity.

We will reject proposals that do not fall within the opportunity scope. The majority of the proposal must fall within the remit of EPSRC.

For more information on the background of this funding opportunity, go to the ‘Additional information’ section.

Duration

The duration of this award is a maximum of two years.

Funding available

The FEC of your project can be up to £187,500.

We will fund 80% of the FEC.

Another linked opportunity which will fund research projects up to £2 million is running in parallel. There is a combined total EPSRC contribution of £12.5 million for both streams.

We reserve the right to manage allocated funding between this and the linked research grants funding opportunity.

What we will not fund

Equipment over £10,000 in value (including VAT) is not available through this funding opportunity. Smaller items of equipment (individually under £10,000) should be in the ‘Directly Incurred – Other Costs’ heading.

Read more about EPSRC’s approach to equipment funding.

How to apply

We are running this funding opportunity on the new UKRI Funding Service. You cannot apply on the Joint Electronic Submissions (Je-S) system.

The project lead is responsible for completing the application process on the Funding Service, but we expect all team members and project partners to contribute to the application.

Only the lead research organisation can submit an application to UKRI.

To apply:

Select ‘Start application’ near the beginning of this Funding finder page.

  1. Confirm you are the project lead.
  2. Sign in or create a Funding Service account. To create an account, select your organisation, verify your email address, and set a password. If your organisation is not listed, email support@funding-service.ukri.org
  3. Answer questions directly in the text boxes. You can save your answers and come back to complete them or work offline and return to copy and paste your answers. If we need you to upload a document, follow the upload instructions in the Funding Service. All questions and assessment criteria are listed in the ‘How to apply’ section on this Funding finder page.
  4. Allow enough time to check your application in ‘read-only’ view before sending to your research office.
  5. Send the completed application to your research office for checking. They will return it to you if it needs editing.
  6. Your research office will submit the completed and checked application to UKRI.

Find out more about How applicants use the UKRI Funding Service and also How research offices use the UKRI Funding Service.

Learn more about Simpler and Better Funding.

Deadline

We must receive your application by 4.00pm UK time on 28 November 2023.

You will not be able to apply after this time.

Make sure you are aware of and follow any internal institutional deadlines.

We will not be returning applications for amendment. If an application is withdrawn prior to peer review or office rejected due to substantive errors in the application, it cannot be resubmitted to the opportunity.

Personal data

Processing personal data

EPSRC, as part of UKRI, will need to collect some personal information to manage your funding service account and the registration of your funding applications.

We will handle personal data in line with UK data protection legislation and manage it securely. For more information, including how to exercise your rights, read our privacy notice.

Publication of outcomes

EPSRC, as part of UKRI, will publish the outcomes of this funding opportunity.

If your application is successful, we will publish some personal information on the UKRI Gateway to Research.

Summary

Word limit: 550

In plain English, provide a summary we can use to identify the most suitable experts to assess your application.

We may make this summary publicly available on external-facing websites, so make it suitable for a variety of readers, for example:

  • opinion-formers
  • policymakers
  • the public
  • the wider research community

Guidance for writing a summary

Clearly describe your proposed work in terms of:

  • context
  • the challenge the project addresses
  • aims and objectives
  • potential applications and benefits

Core team

List the key members of your team and assign them roles from the following:

  • project lead (PL)
  • project co-lead (UK) (PcL)
  • project co-lead (international) (PcL (I))
  • researcher co-lead (RcL)
  • specialist
  • grant manager
  • professional enabling staff
  • research and innovation associate
  • technician
  • visiting researcher

Only list one individual as project lead.

The project co-lead (international) (PcL (I)) role should only be used for applications making use of the UKRI-RCN Money Follows Cooperation agreement or the UKRI-IIASA agreement. We do not otherwise accept project co-lead (international) applicants.

Find out more about UKRI’s new grant roles.

Application questions

Vision and Approach

Create a document that includes your responses to all criteria. The document should not be more than four sides of A4, single spaced in paper in 11-point Arial (or equivalent sans serif font) with margins of at least 2cm. You may include images, graphs, tables. You can have an additional page for a diagrammatic workplan.

For the file name, use the unique UKRI Funding Service number the system gives you when you create an application, followed by the words ‘Vision and Approach’.

Save this document as a single PDF file, no bigger than 8MB. Unless specifically requested, do not include any personal data within the attachment.

If the attachment does not meet these requirements, the application will be rejected.

The UKRI Funding Service will provide document upload details when you apply.

What are you hoping to achieve with and how will you deliver your proposed work?

What the assessors are looking for in your response

For the Vision, explain how your proposed work:

  • is of excellent quality and importance within or beyond the field(s) or area(s)
  • has the potential to advance current understanding, generates new knowledge, thinking or discovery within or beyond the field or area
  • is timely given current trends, context and needs
  • impacts world-leading research, society, the economy or the environment

Within the Vision section we also expect you to:

  • Identify how the project will create a step change in the medicines manufacturing pipeline and who the beneficiaries will be

For the Approach, explain how you have designed your work so that it:

  • is effective and appropriate to achieve your objectives
  • is feasible, and comprehensively identifies any risks to delivery and how they will be managed
  • if applicable, uses a clear and transparent methodology
  • if applicable, summarises the previous work and describes how this will be built upon and progressed
  • will maximise translation of outputs into outcomes and impacts
  • describes how your, and if applicable your team’s, research environment (in terms of the place, and relevance to the project) will contribute to the success of the work

Within the Approach section we also expect you to:

  • demonstrate access to the appropriate services, facilities, infrastructure, or equipment to deliver the proposed work
  • provide a project plan including milestones and timelines in the form of a Gantt chart or similar (additional one-page A4)

Applicant and team capability to deliver

Word limit: 1,500

Why are you the right individual or team to successfully deliver the proposed work?

What the assessors are looking for in your response

Evidence of how you, and if relevant your team, have:

  • the relevant experience (appropriate to career stage) to deliver the proposed work
  • the right balance of skills and expertise to cover the proposed work
  • the appropriate leadership and management skills to deliver the work and your approach to develop others
  • contributed to developing a positive research environment and wider community

The word count for this section is 1,500 words; 1,000 words to be used for R4RI modules and, if necessary, a further 500 words for Additions.

Use the Résumé for Research and Innovation (R4RI) format to showcase the range of relevant skills you and, if relevant, your team (project and project co-leads, researchers, technicians, specialists, partners and so on) have and how this will help deliver the proposed work. You can include individuals’ specific achievements but only choose past contributions that best evidence their ability to deliver this work.

Complete this section using the R4RI module headings listed. Use each heading once and include a response for the whole team, see the UKRI guidance on R4RI. You should consider how to balance your answer, and emphasise where appropriate the key skills each team member brings:

  • contributions to the generation of new ideas, tools, methodologies, or knowledge
  • the development of others and maintenance of effective working relationships
  • contributions to the wider research and innovation community
  • contributions to broader research or innovation users and audiences and towards wider societal benefit
Additions

Provide any further details relevant to your application. This section is optional and can be up to 500 words. You should not use it to describe additional skills, experiences, or outputs, but you can use it to describe any factors that provide context for the rest of your R4RI (for example, details of career breaks if you wish to disclose them).

Complete this as a narrative. Do not format it like a CV.

Within this section you can also demonstrate elements of your responses in visual form if relevant:

  • use images sparingly and only to convey important information that cannot easily be put into words
  • insert each new image onto a new line
  • provide a descriptive legend for each image immediately underneath it (this counts towards your word limit)
  • files must be smaller than 8MB and in JPEG, JPG, JPE, JFI, JIF, JFIF, PNG, GIF, BMP or WEBP format

UKRI has introduced new role types for funding opportunities being run on the new UKRI Funding Service.

For full details, see Eligibility as an individual.

References

Word limit: 1,000

List the references you have used to support your application.

What the assessors are looking for in your response

Include all references in this section, not in the rest of the application questions.

You should not include any other information in this section.

We advise you not to include hyperlinks, as assessors are not obliged to access the information they lead to or consider it in their assessment of your application.

If linking to web resources, to maintain the information’s integrity, include persistent identifiers (such as digital object identifiers) where possible.

You must not include links to web resources to extend your application.

Project partners: contributions

Add details about any project partners’ contributions. If there are no project partners, you can indicate this on the UKRI Funding Service.

A project partner is a collaborating organisation who will have an integral role in the proposed research. This may include direct (cash) or indirect (in-kind) contributions such as expertise, staff time or use of facilities.

Add the following project partner details:

  • the organisation name and address (searchable via a drop-down list or enter the organisation’s details manually, as applicable)
  • the project partner contact name and email address
  • the type of contribution (direct or in-direct) and its monetary value

If a detail is entered incorrectly and you have saved the entry, please remove the specific project partner record and re-add it with the correct information.

For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made.

Project partners: letters (or emails) of support

Word limit 1,000

Upload a single PDF containing the letters or emails of support from each partner you named in the table in the previous ‘contributions’ section.

What the assessors are looking for in your response

If you do not have any project partners, simply add ‘N/A’ into the text box, mark this section as complete and move to the next section.

If you have named project partners in the previous ‘contributions’ section, enter the words ‘attachment supplied’ in the text box.

Each letter or email you provide should:

  • confirm the partner’s commitment to the project
  • clearly explain the value, relevance, and possible benefits of the work to them
  • describe any additional value that they bring to the project

Save letters or emails of support from each partner in a single PDF no bigger than 8MB. Unless specially requested, please do not include any personal data within the attachment.

For the file name, use the unique funding service number the system gives you when you create an application, followed by the words ‘Project partner’.

If the attachment does not meet these requirements, the application will be rejected.

The UKRI Funding Service will provide document upload details when you apply.

Ensure you have prior agreement from project partners so that, if you are offered funding, they will support your project as indicated in the contributions template.

For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made.

Do not provide letters of support from host and project co-leads’ research organisations.

Facilities

Word limit: 250

Does your proposed research require the support and use of a facility?

What the assessors are looking for in your response

If you will need to use a facility, follow your proposed facility’s normal access request procedures. Ensure you have prior agreement so that if you are offered funding, they will support the use of their facility on your project.

For each requested facility you will need to provide the:

  • name of facility, copied and pasted from the facility information list (DOCX, 35KB)
  • proposed usage or costs, or costs per unit where indicated on the facility information list
  • confirmation you have their agreement where required

If you will not need to use a facility, you will be able to indicate this in the UKRI Funding Service.

Resources and cost justification

Word limit: 1,000

What will you need to deliver your proposed work and how much will it cost?

What the assessors are looking for in your response

Justify the application’s more costly resources, in particular:

  • project staff
  • significant travel for field work or collaboration (but not regular travel between collaborating organisations or to conferences)
  • any equipment that will cost more than £10,000
  • any consumables beyond typical requirements, or that are required in exceptional quantities
  • all facilities and infrastructure costs
  • all resources that have been costed as ‘exceptions’

Assessors are not looking for detailed costs or a line-by-line breakdown of all project resources. Overall, they want you to demonstrate how the resources you anticipate needing for your proposed work:

  • are comprehensive, appropriate, and justified
  • represent the optimal use of resources to achieve the intended outcomes
  • maximise potential outcomes and impacts

Ethics and responsible research and innovation (RRI)

Word limit: 500

What are the ethical or RRI implications and issues relating to the proposed work? If you do not think that the proposed work raises any ethical or RRI issues, explain why.

What the assessors are looking for in your response

Demonstrate that you have identified and evaluated:

  • the relevant ethical or responsible research and innovation considerations
  • how you will manage these considerations

If you are collecting or using data, identify:

  • any legal and ethical considerations of collecting, releasing or storing the data including consent, confidentiality, anonymisation, security and other ethical considerations and, in particular, strategies to not preclude further reuse of data
  • formal information standards with which your study will comply

Within this section you can also demonstrate elements of your responses in visual form if relevant:

  • use images sparingly and only to convey important information that cannot easily be put into words
  • insert each new image onto a new line
  • provide a descriptive legend for each image immediately underneath it (this counts towards your word limit)
  • files must be smaller than 8MB and in JPEG, JPG, JPE, JFI, JIF, JFIF, PNG, GIF, BMP or WEBP format

Additional sub-questions (to be answered only if appropriate) will be included in the UKRI Funding Service. These will ask about numbers, species or strain, and justification about the following:

  • genetic and biological risk
  • research involving the use of animals
  • conducting research with animal overseas
  • research involving human participation
  • research involving human tissues or biological samples

How we will assess your application

Assessment process

We will assess your application using the following process.

Panel

Your application will be checked for remit by EPSRC and will then be assessed by an expert panel on 20 February 2024.

The expert panel will assess your proposal against the published criteria and will rank it alongside other applications after which the panel will make a funding recommendation.

EPSRC will make the final funding decision.

Feedback

If your application was discussed by a panel, we will give feedback with the outcome of your application.

Principles of assessment

We support the San Francisco declaration on research assessment and recognise the relationship between research assessment and research integrity.

Find out about the UKRI Principles of Assessment and Decision Making.

We reserve the right to modify the assessment process as needed.

Assessment criteria

The criteria we will assess your application against are:

  • vision
  • approach
  • applicant and team capability to deliver
  • ethics and responsible research and innovation (RRI)
  • resources and cost justification

Find details of assessment questions and criteria under the ‘Application questions’ heading in the ‘How to apply’ section. Please use the ‘What we are looking for’ text in the UKRI Funding Service to assist your understanding of what to include.

Contact details

Get help with your application

If you have a question and the answers aren’t provided on this page

IMPORTANT NOTE: The Helpdesk is committed to helping users of the UKRI Funding Service as effectively and as quickly as possible. In order to manage cases at peak volume times, the Helpdesk will triage and prioritise those queries with an imminent opportunity deadline or a technical issue. Enquiries raised where information is available on the Funding Finder opportunity page and should be understood early in the application process (for example, regarding eligibility or content/remit of an opportunity) will not constitute a priority case and will be addressed as soon as possible.

Contact Details

For help and advice on costings and writing your proposal please contact your research office in the first instance, allowing sufficient time for your organisation’s submission process.

For questions related to this specific funding opportunity please contact: healthcare@epsrc.ukri.org

Any queries regarding the system or the submission of applications through the UKRI Funding Service should be directed to the helpdesk.

Email: support@funding-service.ukri.org

Phone: 01793 547490

Our phone lines are open:

  • Monday to Thursday 8:30am to 5:00pm
  • Friday 8:30am to 4:30pm

To help us process queries quicker, we request that users highlight the council and opportunity name in the subject title of their email query, include the application reference number, and refrain from contacting more than one mailbox at a time.

You can also find information on submitting an application on Improving your funding experience.

Sensitive information

If you or a core team member need to tell us something you wish to remain confidential, email healthcare@epsrc.ukri.org

Include in the subject line: [the funding opportunity title; sensitive information; your UKRI Funding Service application number].

Typical examples of confidential information include:

  • individual is unavailable until a certain date (for example due to parental leave)
  • declaration of interest
  • additional information about eligibility to apply that would not be appropriately shared in the ‘Applicant and team capability’ section
  • conflict of interest for UKRI to consider in reviewer or panel participant selection
  • the application is an invited resubmission

For information about how UKRI handles personal data, read UKRI’s privacy notice.

Additional info

Background

As shown by COVID-19, the UK’s ability to respond to new diseases and health risks is largely dependent on the excellence of our science and the agility of our academic and industrial base. Currently, the timeline for discovery of new medicines through to approval is too long, uncertain, costly and unsustainable to meet our future needs. Our ambition is to revolutionise the UK’s resilience to emerging health threats by transforming the manufacturing pipeline to deliver a step change in the supply of new medicines.

This funding opportunity is being delivered jointly by three EPSRC themes: healthcare technologies, manufacturing and the circular economy, and physical sciences. Through ensuring a focus on manufacturability from the outset, and bringing together expertise from all stages along the pipeline, we hope to facilitate a much more efficient and sustainable pathway for medicines manufacturing.

Research funded through the opportunity will contribute to delivering EPSRC’s transforming health and healthcare priority, as described in our strategic delivery plan, which commits to enabling a more sustainable and resilient healthcare system, integrating manufacturing across scales.

The opportunity also contributes to the UKRI strategic themes in:

  • health, ageing and wellbeing: by advancing people’s health and promoting wellbeing
  • tackling infections: by accelerating new therapeutics
  • building a secure and resilient world: by enhancing national preparedness for risks and threats
  • building a green future: by delivering a more sustainable pathway to deployment for new medicines

Successful UK manufacturing sectors are fundamental to economic growth, prosperity and competitiveness. They also improve the resilience and security of UK supplies and are key to achieving environmental and sustainability targets. However, the sector needs to be innovative to compete on a global scale, including meeting UK net zero targets and addressing UN sustainable development goals.

UKRI’s environmental sustainability strategy further lays out our ambition to actively lead environmental sustainability across our sector. This includes a vision to ensure that all major investment and funding decisions we make are directly informed by environmental sustainability, recognising environmental benefits as well as the potential for environmental harm. As such, you should consider your approach and the potential impacts upon sustainability throughout the development of your programme of work.

Research disruption due to COVID-19

We recognise that the COVID-19 pandemic has caused major interruptions and disruptions across our communities. We are committed to ensuring that individual applicants and their wider team, including partners and networks, are not penalised for any disruption to their career, such as:

  • breaks and delays
  • disruptive working patterns and conditions
  • the loss of ongoing work
  • role changes that may have been caused by the pandemic

Reviewers and panel members will be advised to consider the unequal impacts that COVID-19 related disruption might have had on the capability to deliver and career development of those individuals included in the application. They will be asked to consider the capability of the applicant and their wider team to deliver the research they are proposing.

Where disruptions have occurred, you can highlight this within your application if you wish, but there is no requirement to detail the specific circumstances that caused the disruption.

Supporting documents

Equality impact assessment (PDF, 342KB)

Funding opportunity question and answer document (PDF, 115KB)

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